Article Text

Download PDFPDF
Case report
Hypereosinophilic dermatitis: generalised lichenification and gyrate erythema as the sole manifestation of idiopathic hypereosinophilic syndrome
  1. Deepika Yadav1,
  2. Ananya Sharma1,
  3. Shipra Agarwal2 and
  4. Vishal Gupta1
  1. 1 Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India
  2. 2 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
  1. Correspondence to Dr Vishal Gupta; doctor.vishalgupta{at}


A 22-year-old female presented with generalised lichenification and severe pruritus, along with multiple annular papules and concentric plaques over trunk and extremities for the last 3 years. Her haematological investigations revealed leucocytosis with peripheral blood eosinophilia and raised serum IgE levels. Skin biopsy showed perivascular and interstitial infiltrate of eosinophils and lymphocytes in the dermis. Bone marrow examination showed myeloid hypercellularity with increased number of eosinophils, but no atypical cells. Cytogenetic studies did not reveal any chromosomal alterations. No systemic involvement was found on imaging. A diagnosis of idiopathic skin-limited hypereosinophilic syndrome was made. She was treated with tapering doses of oral prednisolone and weekly methotrexate with significant improvement in skin lesions and pruritus in 2 months, which was maintained at 7-month follow-up.

  • dermatology
  • haematology (drugs and medicines)
View Full Text

Statistics from


  • Contributors DY, AS, SA and VG were involved in the conception and design, acquisition of data or analysis and interpretation of data.DY, AS, SA and VG also drafted the article and revised it.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.