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Case report
Unusual case of adult familial Menetrier disease in siblings
  1. Emily Brownson1,
  2. Adrian J Stanley2,
  3. Prakash Konanahalli1 and
  4. John P Seenan1
  1. 1 Department of Gastroenterology, Queen Elizabeth University Hospital, Glasgow, UK
  2. 2 Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK
  1. Correspondence to Dr Emily Brownson, emilybrownson{at}


Menetrier disease is a rare disease characterised by hyperplasia of the gastric epithelium and large gastric folds. We present a case of a 58-year-old woman who was referred with iron deficiency anaemia, with a family history of a sibling who had undergone gastrectomy for presumed gastric malignancy. Endoscopy showed prominent gastric mucosal folds and biopsies showed hyperplastic gastric mucosa, with prominent foveolar hyperplasia suggestive of Menetrier disease. Further information about her brother’s diagnosis was sought, and it was found that his pathology after gastrectomy showed diffuse glandular hyperplasia also in keeping with Menetrier disease. Adult familial Menetrier disease has so far been a rarity in the literature—review elicits five previous cases of this presentation in siblings.

  • gastroenterology
  • endoscopy
  • stomach and duodenum

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  • Contributors EB: compiled the manuscript , under the mentorship of JPS and with guidance from all authors. AJS and PK: provided the figures in the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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