Article Text

Download PDFPDF
Case report
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus associated with lung carcinoma
  1. Luís Santiago1,
  2. Rosa Mascarenhas2,
  3. Óscar Tellechea1 and
  4. Margarida Gonçalo1
  1. 1 Department of Dermatology, Hospital and University Centre of Coimbra, Coimbra, Portugal
  2. 2 Department of Dermatology, Hospital Distrital da Figueira da Foz, Figueira da Foz, Portugal
  1. Correspondence to Dr Luís Santiago; luisgsantiago2{at}gmail.com

Abstract

Specific vesiculobullous skin lesions in lupus erythematosus (LE) are rare and must be differentiated from toxic epidermal necrolysis (TEN), TEN-like dermatoses and other vesiculobullous conditions. We report a patient with typical subacute cutaneous lupus erythematous that progressed with large sheet-like areas of epidermal detachment and Nikolsky sign resembling TEN. She had a serological profile suggestive of underlying connective tissue disease, histological findings of interface dermatitis with a lymphocytic infiltrate, positive direct immunofluorescence, resolution with immunomodulation and lack of a culprit drug, features observed in TEN-like cutaneous lupus erythematous. Furthermore, she was diagnosed with lung carcinoma, an association that has been previously reported. Differentiating a bullous eruption in the context of pre-existing LE remains difficult requiring a thorough analysis of clinical and histopathological data.

  • dermatology
  • rheumatology
View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors LS: wrote the paper and data collection. RM and ÓT: critical revision of the article. MG: final approval of the version to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.