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Case report
Heterochromia irides and mistaken identity of retinoblastoma
  1. Moh'd Saleh Abu-Ain1,2,
  2. Raed Shatnawi1,
  3. Yacoub A Yousef3 and
  4. Patrick Watts4
  1. 1Ophthalmology, Hashemite University Faculty of Medicine, Zarqa, Jordan
  2. 2Ophthalmology Department, Prince Hamzah Hospital, Amman, Jordan
  3. 3King Hussein Cancer Center, Amman, Jordan
  4. 4Ophthalmology Department, University Hospital of Wales, Cardiff, UK
  1. Correspondence to Mr Moh'd Saleh Abu-Ain; abuain{at}


Retinoblastoma is the most common intraocular malignancy of infancy which frequently manifests with a white pupillary reflex. We report a case of delayed presentation of a child with retinoblastoma in his left eye because parents thought the change in iris colour in this eye was due to the innocent heterochromia irides that was previously diagnosed in his elder sibling. This late presentation necessitated enucleation of the affected eye followed by chemotherapy.

  • ophthalmology
  • glaucoma
  • retina
  • head and neck cancer
  • paediatric oncology
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  • Contributors MSA-A, the main author of the case. I have received the case after being seen by my colleague, I have made the clinical evaluation, examination and further referral for specialised center and contacted the family for have further evaluation of other members of the family as well as consenting and photographing. I have written the initial manuscript and further modification after being revised by my coauthors and I have submitted the case. RS: he has received the case in his clinic and intiated the managemennt process. He has examined the case in the clinic and further initiated the management plan. He ordered the initial investigations. YAY: he is the ocular oncologist and the surgeon who performed the surgery and enucleated the involved eye. He is following up the case. PW: he is my supervising consultant who I have consulted him in regard to the case who helped in further explaining and writing up the case. He made the final edition of the case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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