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  • A case of isolated cortical venous thrombosis presenting radiographically as a subacute multifocal leukoencephalopathy, and review of literature

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Unusual association of diseases/symptoms
Case report
A case of isolated cortical venous thrombosis presenting radiographically as a subacute multifocal leukoencephalopathy, and review of literature
  1. Charles Francis Palmer1,
  2. Farnaz Khalighinejad2,
  3. Adalia Jun-O'Conell2 and
  4. Carolina Ionete2
  1. 1 Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA
  2. 2 Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
  1. Correspondence to Dr Farnaz Khalighinejad; Farnaz.Khalighinejad{at}umassmed.edu

Abstract

A 55-year-old man presented with brief seizure with associated acute aphasia, right head turn and subsequent generalised convulsion. On imaging, he was found to have patchy juxtacortical and cortical T2 hyperintensity with high radiographic suspicion for subacute multifocal leukoencephalopathy. Serum and cerebrospinal fluid testing were unremarkable. Clinically, the patient recovered completely and had no recurrence of symptoms. On follow-up MRI 1 month later, the T2 hyperintensity had resolved almost entirely while hypointensity on susceptibility-weighted angiography MRI remained, suggesting isolated cortical venous thrombosis.

  • epilepsy and seizures
  • neuroimaging
  • stroke
  • infection (neurology)

https://doi.org/10.1136/bcr-2019-230915

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    Footnotes

    • Contributors CFP contributed to data acquisition, interpretation of data, drafting of article and critical revision of the manuscript for important intellectual content. FK contributed to data acquisition, interpretation of data, drafting of article and critical revision of the manuscript for important intellectual content. AJ contributed to data acquisition, interpretation of data, drafting of article and critical revision of the manuscript for important intellectual content. CI contributed to data acquisition, interpretation of data, drafting of article and critical revision of the manuscript for important intellectual content.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.