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Case report
Rosuvastatin-related rhabdomyolysis causing severe proximal paraparesis and acute kidney injury
  1. Kosar Hussain1 and
  2. Anil Xavier2
  1. 1General Medicine, Goulburn Valley Health, Shepparton, Victoria, Australia
  2. 2Nephrology and General Medicine, Goulburn Valley Health, Shepparton, Victoria, Australia
  1. Correspondence to Dr Kosar Hussain; dockohu{at}


We describe the case of a 76-year-old man who presented with bilateral lower limb weakness associated with decreased urine output. His initial blood results showed acute kidney injury (AKI) stage 3 with substantially raised serum creatine kinase concentration of 37 950 IU/L (normal range <171 U/L). He had been on high-dose rosuvastatin for 4 years with a recent brand change occurring 1 week prior to onset of symptoms. There was no history of pre-existing neuromuscular disease. Statin-related rhabdomyolysis was suspected and rosuvastatin was withheld. His muscle strength gradually improved. He required haemodialysis for 10 weeks. He was discharged home after a complicated course of hospitalisation. His renal function improved and he became dialysis-independent; however, he was left with residual chronic kidney disease.

  • Acute renal failure
  • Unwanted effects / adverse reactions
  • Muscle disease
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  • Contributors KH has obtained consent and written the manuscript. AX has reviewed the final manuscript and approved it. Both were involved in patient care.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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