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Alport’s syndrome and intracranial aneurysm: mere coincidence or undiscovered causal relationship
  1. Subhasish Bose1,
  2. Samata Pathireddy2,
  3. Krishna M Baradhi3 and
  4. Narothama Reddy Aeddula4,5
  1. 1 Department of Nephrology, Lynchburg Nephrology, Lynchburg, Virginia, USA
  2. 2 Department of Internal Medicine, Deaconess Health System, Evansville, Indiana, USA
  3. 3 Department of Nephrology, University of Oklahoma School of Community Medicine, Tulsa, Oklahoma, USA
  4. 4 Department of Nephrology, Deaconess Health System, Evansville, Indiana, USA
  5. 5 Department of Medicine, Indiana University School of Medicine, Evansville, Indiana, USA
  1. Correspondence to Dr Samata Pathireddy, drspathireddy{at}


A 44-year-old Caucasian man with a history of deceased donor renal transplant for end-stage renal disease from Alport’s syndrome (AS), presented with a spontaneous subarachnoid haemorrhage and hydrocephalus. Following an external ventricular drain for the hydrocephalus, a CT angiography revealed a dissection of the left vertebral artery extending into vertebro-basilar junction necessitating a bypass between left occipital artery to left posterior inferior cerebellar artery. He had a posterior fossa Craniectomy, C1 laminectomy and coiling off, of the left vertebral artery. Postprocedure course was prolonged but uneventful with complete recovery and normal renal function 18 months postpresentation. AS, a disease caused by abnormalities in the synthesis of type IV collagen, can cause aneurysms with severe and permanent neurological sequalae. We present a case of AS with intracranial arterial dissection with potential life-threatening consequences and discuss the genetic and molecular basis of AS along with review of the relevant literature.

  • neuroimaging
  • neuro itu
  • interventional radiology
  • renal transplantation
  • stroke

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  • Contributors SB involved in the planning, conception, acquisition of data including images, patient consent, and NRA, SP and KMB helped with the final drafting of the case report. SB and NRA are the first authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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