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Beer: an uncommon cause of anaphylaxis
  1. Joana Sofia Pita1,
  2. Nuno Sousa2,
  3. Borja Bartolome3,
  4. Carlos Loureiro1 and
  5. Ana Todo Bom1
  1. 1 Allergy & Clinical Immunology Deparment, Coimbra Universitary Hospital Centre, Coimbra, Portugal
  2. 2 Allergy & Clinical Immunology Consult, Santo André Hospital, Leiria, Portugal
  3. 3 Roxall. R&D Department, Bilbao, Spain
  1. Correspondence to Dr Joana Sofia Pita, joana.s.pita{at}


Beer is one of the most consumed alcoholic beverages worldwide but allergic reactions to this beverage are uncommon. The authors present a case report of a 32-year-old male patient, sent to our Allergy and Immunology Department due to anaphylaxis minutes after Franziskaner beer ingestion. He tolerates all other alcoholic beverages. Prick tests to cereals were positive to wheat, corn and barley, as well as to peach. Prick-to-prick tests were performed with nine beer brands, all positive. Immunoglobulin (Ig)E to Pru p 3 was 14.8 kU/L. Sodium dodecyl sulfate polyacrylamide gel electrophoresis inhibition immunoblotting was performed with the Franziskaner beer extract in solid phase and both cereal extracts (wheat, barley and corn) and Pru p 3 as inhibitors. Extracts from wheat, barley and corn, and Pru p 3 purified protein were able to inhibit almost totally the IgE-binding to the Franziskaner beer extract. It seemed likely that the IgE-binding bands detected in the Franziskaner beer extract could be an LTP from cereals.

  • immunology
  • medical management

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  • Contributors JSP: wrote the case report; NS: oriented the patient; performed the clinical history, skin prick tests and prick-to-prick tests to all beers. BB: performed the analysis through immunoblotting. CL and ATB: review and final corrections.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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