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Primary isolated hepatosplenic sarcoidosis mimicking malignancy and causing symptomatic hypercalcaemia
  1. Tarek Haykal,
  2. Saira Sundus,
  3. Ghassan Bachuwa and
  4. Rizwan Danish
  1. Hurley Medical Center, Flint, Michigan, USA
  1. Correspondence to Dr Ghassan Bachuwa, gbachuw2{at}


This is a case of a 67-year-old woman, known to have multiple medical problems, mainly papillary thyroid cancer status post-total thyroidectomy and cervical neck dissection in addition to radioactive iodine currently in remission for 1 year, who presented to the hospital with severe weakness and fatigue. The initial workup showed significant hypercalcaemia and suppressed Parathyroid hormone (PTH). The patient was treated with hydration and pamidronate and her hypercalcaemia and symptoms improved. The differential was wide, however, a CT scan of the chest, abdomen and pelvis did show multiple liver and splenic nodular lesions; therefore, malignancy was the highest possible diagnosis. Biopsy of the splenic lesion confirmed the diagnosis of sarcoidosis. Therefore, the patient was diagnosed with primary isolated nodular hepatosplenic sarcoidosis mimicking malignancy and causing significant symptomatic hypercalcaemia.

  • calcium and bone
  • rheumatology
  • endocrinology

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  • Patient consent for publication Obtained.

  • Contributors TH: idea creation, data acquisition, data analysis, manuscript writing. SS: data analysis, manuscript writing and editing. GB: data analysis, manuscript editing. RD: primary attending, manuscript editing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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