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CASE REPORT
Tubulointerstitial nephritis and uveitis syndrome in a female adult
  1. Tiago J Carvalho1,
  2. Rita Calça1,
  3. João Cassis2 and
  4. Artur Mendes1
  1. 1 Nephrology, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal
  2. 2 Department of Pathology, Centro Hospitalar de Lisboa Ocidental - Hospital de Egas Moniz, Lisboa, Portugal
  1. Correspondence to Dr Tiago J Carvalho, tiagojc18{at}hotmail.com

Abstract

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease characterised by the association of acutetubulointerstitial nephritis and uveitis. It affects mainly children and young women. Drugs and infections may be precipitating factors. It is a diagnosis of exclusion. The mainstays of treatment are topical and systemic corticosteroids. Prognosis is usually favourable. We report a case of TINU which occurred in our unit. A 37-year-old woman presented with an influenza-like illness, bilateral ocular pain and blurred vision. Ophthalmological evaluation revealed bilateral anterior uveitis and later renal involvement was seen as acute tubulointerstitial nephritis. A diagnosis of TINU was assumed after exclusion of other systemic diseases. She was treated with topical corticosteroids for the uveitis and evolved favourably, with resolution of ocular symptoms and normalisation of serum creatinine and proteinuria. This case highlights the importance of a high degree of clinical suspicion to make the diagnosis of TINU syndrome.

  • renal medicine
  • acute renal failure
  • proteinurea
  • ophthalmology
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Footnotes

  • Patient consent for publication Obtained.

  • Contributors TJC: main author. RCç: nephrology resident, contributed to writing and patient follow-up. JãC: pathologist responsible for kidney biopsy analysis and for providing images and their captions. AM: head of interventional nephrology, responsible for article review.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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