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Synovial sarcoma in an HIV-positive pregnant woman and review of literature
  1. Folasade Akhanoba1,
  2. Rabia Zill-E-Huma1,
  3. Rob Pollock2 and
  4. Sarah J E Edwards3
  1. 1 Obstetrics and Gynaecology, Lister Hospital, Stevenage, UK
  2. 2 Trauma and Orthopaedics, Royal National Orthopaedic Hospital, Stanmore, UK
  3. 3 Hertfordshire HIV Service, Chelsea and Westminster Hospital, London, UK
  1. Correspondence to Miss Rabia Zill-E-Huma, rabia.zill-e-huma{at}


We present a first case of synovial sarcoma in an HIV-positive pregnant woman. This 28-year-old woman was diagnosed with synovial sarcoma, a high-grade malignant soft tissue sarcoma, involving her left thigh during the first trimester of her pregnancy. She underwent surgical treatment in the form of hip disarticulation at 30 weeks’ gestation. She was subsequently delivered by emergency caesarean section (CS) at 34 weeks’ gestation when she presented with wound sepsis and a scan revealed static growth in a small for gestational age fetus. Prompt diagnosis and treatment of this aggressive tumour is important and should involve a multidisciplinary approach, with a balanced consideration of the maternal and fetal outcomes.

  • pregnancy
  • orthopaedics
  • HIV / aids
  • oncology

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  • Patient consent for publication Obtained.

  • Contributors R.Z-E-H. obtained written consent from the patient to write up her case. All authors (F.A., R.Z-E-H., R.P. and S.E.) took part in the gathering of the information required from the patient’s history and notes. F.A. carried out the literature review. F.A. and R.Z-E-H. were responsible for the initial draft of the work. All authors (F.A., R.Z-E-H., R.P. and S.E.) participated in the revision and final approval of the content. All authors (F.A., R.Z-E-H., R.P. and S.E.) agree with the content of the manuscript and there are no conflicts of interests between them.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.