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Clear cell, giant myoepithelioma of tongue base: a diagnostic and surgical challenge
  1. Prasanna Kumar Saravanam,
  2. Vinoth Manimaran and
  3. Rashmika Rajendran
  1. ENT, Head and Neck Surgery, Sri Ramachandra University Medical College, Chennai, Tamil Nadu, India
  1. Correspondence to Dr Vinoth Manimaran, vinomb88{at}


Clear cell variant is a rare histological type of myoepithelioma seen in parotid and soft palate. This article describes clear cell variant of myoepithelioma in the tongue base, which has not been reported in the literature so far. A 34-year-old man presented with dysphagia and foreign body sensation of throat. Video laryngostroboscopy using a 70° rigid telescope showed a smooth globular mass in the oropharynx arising from the tongue base. Based on clinical and radiological findings, the lesion was considered as benign. Fine needle aspiration cytology was not attempted fearing risk of bleeding, aspiration and airway compromise. Hence, an excisional biopsy followed by definitive histopathological examination without frozen section was planned. The patient underwent coblator-assisted excision and subsequently sent for histopathological analysis. There were cuboidal cell nests with abundant clear cytoplasm which stained positive for p63 by immunohistochemistry. This helped in establishing the diagnosis of clear cell myoepithelioma.

  • ear, nose and throat/otolaryngology
  • head and neck cancer

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  • Contributors The first author, PKS is a Senior Consultant ,Professor and Resident guide in Sri Ramachandra University hospital, Chennai. He was the main surgeon of the patient in this study. He also helped the VM(Corresponding author) in the write-up of this article . His ideas and experience has helped in shaping up the article for possible publication. The second and corresponding author, VM is a senior resident and registrar in the same university hospital. He was the second main surgeon and did the main write-up of the article.He did an extensive research and reviews regarding myoepithelioma before beginning to write the article. The third author, RR is a third year resident trainee in Otolaryngology. She actively involved herself in peri-operative management of this patient and also in collecting photographs of CT scan, histology slides and IHC slides. She also helped the corresponding author in preparing the main manuscript. Thank you.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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