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Anaphylaxis to patent blue dye in a 17-year-old boy
  1. Mélanie Leung1,
  2. Christine McCusker2 and
  3. Moshe Ben-Shoshan3
  1. 1 Department of Medicine, McGill University, Montreal, Quebec, Canada
  2. 2 Division of Pediatric Allergy Immunology and Dermatology, Department of Pediatrics, McGill University Health Center, Montreal, Quebec, Canada
  3. 3 Division of Allergy Immunology and Dermatology, Department of Paediatrics, McGill University Health Centre, Montreal, Quebec, Canada
  1. Correspondence to Mélanie Leung, melanie.leung{at}


Patent blue V dye (PBV) is frequently used as a perioperative drug for lymphangiography, as well as a food additive. Hypersensitivity to PBV is poorly documented in adults and had not been previously described in children. The diagnosis of PBV allergy depends on corroboration of history consistent with an IgE-mediated reaction and confirmatory skin tests. We present in this paper a paediatric case of PBV anaphylaxis and of biphasic reaction that exemplifies the challenges involved in diagnosing and managing this rare but potentially life-threatening allergic reaction.

  • paediatrics (drugs and medicines)
  • drug therapy related to surgery
  • immunology
  • medical management
  • unwanted effects / adverse reactions

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  • Patient consent for publication Parental/guardian consent obtained.

  • Contributors ML was responsible for collecting the data, writing the case report, completing the documents related to the submission, revising and submitting the manuscript. CM was the physician who assessed the patient during his allergic reaction, made the diagnosis, reviewed the documents regarding the case report and revised the manuscript. MB-S was responsible for the investigations of the patient’s allergy, for reviewing the documents related to the case report, to help for logistics and revising the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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