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CASE REPORT
Solid papillary thyroid carcinoma with Hashimoto’s thyroiditis: description of a further case with challenging cytological features
  1. Franco Fulciniti1,
  2. Jessica Barizzi1,
  3. Pierpaolo Trimboli2 and
  4. Luca Giovanella2
  1. 1 Pathology, Institute of Pathology, Locarno, Switzerland
  2. 2 Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
  1. Correspondence to Dr Franco Fulciniti, franco.fulciniti{at}gmail.com

Abstract

Solid papillary thyroid carcinoma (SV-PTC) is a rare variant which is mainly observed in young patients with a history of exposure to ionising radiations. Neoplasms belonging to such category generally carry RET-PTC (REarranged during Transfection- Papillary Thyroid Carcinoma) fusions and seem to have a slightly worse prognosis with respect to classical and follicular variants of papillary thyroid carcinoma (PTC), though consistent prognostic and survival data are scarce. SV-PTC should be differentiated from trabecular-insular poorly differentiated thyroid carcinomas, which occur in a different age group and carry a dismal prognosis. These latter tumours do not show the typical nuclear features of PTC and show tumour necrosis with an high mitotic activity. In this report a further case of SV-PTC is described which was associated to Hashimoto’s thyroiditis, a finding never described in the cytological literature up to now for SV-PTC; this association created further differential diagnostic problems. The neoplasm displayed RET-PTC1 fusion.

  • endocrinology
  • pathology
  • endocrine cancer
  • head and neck cancer
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Footnotes

  • Contributors FF and PT saw the patient and made the diagnosis. FF and JB edited the manuscript. PT and LG were responsible for the patient’s treatment and coauthored this paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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