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Resistant type II cryoglobulinaemic vasculitis successfully treated with bortezomib in a patient with SLE
  1. Katherine Dutton1,5,
  2. Sinisa Savic1,5,
  3. Roger Owen2 and
  4. Edward Vital1,3,5
  1. 1 Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK
  2. 2 Department of Haematological Malignancy Diagnostic Service, Leeds Teaching Hospitals NHS Trust, Leeds, UK
  3. 3 National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, UK
  4. 5 Department of Rheumatology, Leeds Teaching Hospitals NHS Trust, Chapel Allerton Hospital, Leeds, UK
  1. Correspondence to Dr Edward Vital, E.M.J.Vital{at}


We report an interesting case of hepatitis C virus-negative type II cryoglobulinaemic vasculitis (CV) in a patient with a background history of systemic lupus erythematosus. The type II CV became less responsive to traditional treatments over time and culminated in an intensive care unit admission with critical multiorgan failure. A detailed flow cytometric evaluation of the bone marrow proved to be helpful in treatment. It demonstrated that bortezomib was a viable alternative treatment option for the type II CV. The patient received bortezomib and has made a full and durable recovery.

  • connective tissue disease
  • vasculitis
  • systemic lupus erythematosus
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  • Contributors KD: interviewed the patient and constructed the initial and final drafts of the written piece. EV: provided direct clinical care in the case and edited the article. SS and RO: provided direct clinical care and edited the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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