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Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with aflibercept
  1. Weh Loong Gan1,2 and
  2. Vernon W Long1,2
  1. 1 The University of Leeds, Leeds, UK
  2. 2 Ophthalmology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
  1. Correspondence to Dr Weh Loong Gan, wehloong.gan{at}


Peripapillary choroidal neovascularisation (PPCNV) associated with optic disc drusen is a rare complication that can result in severe vision impairment in children. We report the first case of paediatric PPCNV secondary to optic disc drusen successfully treated with intravitreal aflibercept. A 6-year-old girl presented with a one week history of reduced vision in her right eye with best-corrected visual acuity of 20/500. Fundus examination revealed bilateral elevated discs with a peripapillary pigmentary lesion in the right eye. Optical coherence tomography of the right eye showed marked subfoveal fluid. Both B-scan ultrasonography and fundus autofluorescence demonstrated findings consistent with optic disc drusen. Diagnosis of PPCNV was further confirmed on fluorescein fundus angiography. The child received three intravitreal aflibercept injections with complete resolution of the subfoveal fluid. Her visual acuity improved to 20/25 with no recurrence at a 16-month follow-up. No adverse side effects were reported.

  • macula
  • retina
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  • Contributors WLG: involved in case write-up, literature search and manuscript submission. VWL: involved in patient care and management.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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