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CASE REPORT
Autoimmune myelofibrosis: a rare haematological involvement in systemic lupus erythematosus
  1. Nabil Belfeki1,
  2. Gopinath Shankarasivam1,
  3. Damienne Declerck2 and
  4. Sylvain Diamantis1
  1. 1 Internal Medicine and Infectious Disease Department, Centre Hospitalier Sud Ile de France, Melun, France
  2. 2 Pathological Laboratory, Laboratoire d’anatomopathologie d’Avon, Avon, France
  1. Correspondence to Dr Nabil Belfeki, belfeki.nabil{at}gmail.com

Abstract

Autoimmune myelofibrosis is a distinct clinicopathological entity that occurs with autoimmune disorders. We report the case of a 44-year-old woman admitted with pancytopenia and clinical features of systemic lupus erythematosus, Sjogren’s syndrome and antiphospholipid antibodies syndrome. Bone marrow biopsy showed decreased global cells and an increase of reticulin fibres on argentic coloration, consistent with myelofibrosis. The JAK2 V617, Myeloproliferative leukemia (MPL) and calreticulin mutations were negative. The patient’s condition improved after treatment with hydroxychloroquine, vitamin K antagonists and prednisone.

  • haematology (incl blood transfusion)
  • immunology
  • systemic lupus erythematosus
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Footnotes

  • Contributors NB, GS, SD contribute to the elaboration of the clinical text and the management of the patient. DD performed an interpretation of the marrow biopsy.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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