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Ocular hypertension secondary to high endogenous steroid load in Cushing’s disease
  1. Sofia Noor Habib1,
  2. Zhiheng Lin2 and
  3. Narman Puvanachandra1
  1. 1 Ophthalmology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK
  2. 2 Ophthalmology, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK
  1. Correspondence to Zhiheng Lin, zlin{at}


This case report describes a 35-year-old Caucasian man who was referred to the glaucoma clinic with high intraocular pressure (IOP) after routine optometrist assessment. He was diagnosed with ocular hypertension (OHT) and the management plan was for monitoring without treatment. Three months later, he presented to the endocrine clinic with symptoms of Cushing’s disease and was diagnosed with an adrenocorticotropic hormone secreting pituitary microadenoma. His symptoms preceded his presentation at both departments by 5 years. He underwent definitive surgical treatment of his adenoma via transsphenoidal resection. At 1-year follow-up in glaucoma clinic, it was noted that his IOP had normalised. Due to his high endogenous cortisol level at diagnosis, long disease duration, the pattern of IOP rise and subsequent normalisation after treatment, it is suggestive that his OHT is secondary to his Cushing’s disease. There are infrequent reports of this association in published literature.

  • glaucoma
  • ophthalmology
  • pituitary disorders
  • endocrinology

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  • Contributors SNH performed the literature review, and drafted the case report. ZL performed the same as SNH but to a lesser degree. NP suggested the case for publication and suggested content changes.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.