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Large cell neuroendocrine carcinoma of the uterine cervix
  1. Amir Habeeb1 and
  2. Hany Habeeb2
  1. 1 Department of Obstetrics and Gynaecology, University College London, London, UK
  2. 2 Department of Obstetrics and Gynaecology, Medway Maritime Hospital, Gillingham, UK
  1. Correspondence to Amir Habeeb, amirhabeeb{at}


We report a case of large cell neuroendocrine carcinoma of the uterine cervix. A 33-year-old woman presented with a 4-month history of irregular vaginal bleeding and suspicious cervix. Transvaginal ultrasound showed a 3×3.8 cm cervical mass with a marked increase in the blood flow. MRI pelvis showed an exophytic tumour with left external iliac lymph node metastasis. Immunohistochemistry of the tumour cells showed strong positivity for the neuroendocrine markers synaptophysin and a very high Ki67 proliferation index. A diagnosis of high-grade large cell neuroendocrine carcinoma of the uterine cervix was made with FIGO stage IIA2. She was treated with chemotherapy and palliative radiotherapy but died 21 months after presenting. Neuroendocrine tumour of the uterine cervix is an extremely aggressive cancer with the late presentation—the need for a more rigorous treatment protocol as well as potential screening methods could improve outcomes for these patients.

  • obstetrics and gynaecology
  • gynecological cancer

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  • Patient consent for publication Not required.

  • Contributors AH: wrote all parts of the case report with help of the patient notes. HH: saw the patient who presented in the clinic and managed her throughout.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.