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CASE REPORT
Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: technical note
  1. Michal Zawadzki1,
  2. Jerzy Walecki1,
  3. Boguslaw Kostkiewicz2,
  4. Kacper Kostyra2,
  5. Monica Smith Pearl3,4,
  6. Meiyappan Solaiyappan3,
  7. Piotr Walczak3 and
  8. Miroslaw Janowski3
  1. 1 Department of Radiology, Centre of Postgraduate Medical Education, Warsaw, Poland
  2. 2 Department of Neurosurgery, Central Clinical Hospital of Ministry of the Interior and Administration, Warsaw, Poland
  3. 3 Department of Radiology, Johns Hopkins Hospital, Baltimore, Maryland, USA
  4. 4 Department of Radiology, Children’s National Medical Center, District of Columbia, USA
  1. Correspondence to Dr Miroslaw Janowski, mjanows1{at}jhmi.edu

Abstract

Patients with malignant brain tumors have a poor prognosis. The blood–brain barrier (BBB) is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has recently been shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma supplied by the catheter and facilitates predictable drug targeting. Moreover, PET imaging has shown that IA rather than intravenous delivery of bevacizumab results in accumulation in the brain, providing a strong rationale for using the IA route. We present a patient with recurrent butterfly glioblastoma enrolled in a first-in-man MRI-guided neurointervention for targeted IA drug delivery.

  • mri
  • brain
  • intervention
  • technique
  • malignant
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Footnotes

  • Contributors MZ: planned treatment and performed procedure, analyzed data and edited manuscript. JW: planned treatment and edited manuscript. BK: planned treatment and edited manuscript. KK: planned treatment and took care of patient on daily basis. MSP and MS: prepared virtual reality visualization. PW: planned procedure, analyzed data, edited manuscript and prepared figures. MJ: planned treatment and performed procedure, analyzed data, drafted manuscript and approved its final form.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval Central Clinical Hospital of Ministry of the Interior and Administration.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All imaging data can be shared on request.

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