Article Text
Unexpected outcome (positive or negative) including adverse drug reactions
CASE REPORT
Anaphylaxis after treatment with recombinant factor VIII: investigation and therapeutic challenge
Abstract
We report a 10-year-old patient with haemophilia A developing anaphylaxis to recombinant factor VIII (octocog alfa). Allergic reactions, and especially anaphylactic events, are rare in patients with haemophilia A. The nature of these reactions is not fully understood. Here, we demonstrate a type I hypersensitivity reaction using sodium dodecyl sulfate-polyacrylamide gel electrophoresis immunoblotting assay. This test revealed itself as an essential diagnostic tool, as it allowed us to choose an alternative treatment (moroctocog alfa). Its safety was later confirmed by an uneventful challenge test.
- paediatrics (drugs and medicines)
- unwanted effects/adverse reactions