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Chronic meningoencephalitis with mixed pathology mimics progressive supranuclear palsy
  1. Marian L Dale1,
  2. Deniz Erten-Lyons2,
  3. Frank Bittner3 and
  4. Randy Woltjer2
  1. 1 Department of Neurology, Medical University of South Carolina - College of Medicine, Charleston, South Carolina, USA
  2. 2 Departments of Neurology and Pathology, Oregon Health & Science University, Portland, Oregon, USA
  3. 3 Department of Neurology, University of Iowa, Iowa City, Iowa, USA
  1. Correspondence to Dr Marian L Dale, dalem{at}


We report a case of a progressive supranuclear palsy-like phenotype with rapidly progressive dementia and prominent language and executive dysfunction. Pathological examination revealed no midbrain or white matter tauopathy, but rather chronic meningoencephalitis and other mixed pathology. The cerebrospinal fluid (CSF) in this case showed a novel antibody against central nervous system and renal tissue.

  • movement disorders (other than parkinsons)
  • dementia due to medical condition

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  • Contributors MLD initiated the collaborative project and drafted the paper. She is the guarantor. DE-L revised the paper. FB revised the paper. RW analysed the data and revised the paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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