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Wolf in the sheep’s clothing: intestinal angioedema mimicking infectious colitis
  1. Asif Mehmood1,
  2. Hafez Mohammad Ammar Abdullah2,
  3. Faisal Inayat3 and
  4. Waqas Ullah1
  1. 1 Internal Medicine, Abington Hospital - Jefferson Health, Abington, Pennsylvania, USA
  2. 2 Internal Medicine, University of South Dakota Sanford School of Medicine, SD, USA
  3. 3 Allama Iqbal Medical College, Lahore, Pakistan
  1. Correspondence to Waqas Ullah, waqasullah.dr{at}


Hereditary angioedema (HAE) is a relatively rare clinical entity that can potentially cause life-threatening airway or intestinal oedema, patients with the latter usually presents with symptoms of gastroenteritis like vomiting, diarrhoea and abdominal pain. Here, we present a unique case of a less recognised type of HAE that is type III in a patient who presented with signs and symptoms consistent with infectious colitis. She previously had similar episodes and was managed multiple times with antibiotics, with no satisfactory response. There, she underwent extensive diagnostic evaluation. On the basis of findings of further investigations on the current visit, she was eventually diagnosed with intestinal angioedema. To the best of our knowledge, the present paper represents the third reported case of type III HAE-induced intestinal angioedema. Additionally, we undertake a literature review of HAE.

  • gastroenterology
  • small intestine

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  • Contributors AM contributed to the case presentation, performed the literature review. HMAA contributed to the discussion. FI performed the literature review, contributed to the discussion and revised the manuscript for important intellectual content. WU performed the literature search, contributed to the discussion and gave the final approval for the version published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.