Article Text

Download PDFPDF
Unusual case of cellulitis due to primary cutaneous histoplasmosis
  1. Vishesh Paul1 and
  2. Michael S Kuhlenschmidt2
  1. 1 Pulmonary and Critical Care Medicine, Carle Foundation Hospital, Urbana, Illinois, USA
  2. 2 Internal Medicine, University of Illinois College of Medicine, Urbana, Illinois, USA
  1. Correspondence to Dr Vishesh Paul, visheshpaul{at}


A 63-year-old white man with a history of rheumatoid arthritis on adalimumab was admitted to the hospital for left arm swelling and erythema. On physical examination, the patient was afebrile and non-toxic appearing and there was tense oedema of the left forearm. Initial laboratory work was unremarkable except for elevated inflammatory markers. MRI of the arm showed non-specific findings of inflammation. The patient was started on empiric antibiotics but did not improve. Given the patient’s immunosuppression, early consideration was given to fungal or mycobacterial causes. Initial serum fungal studies were negative and the patient was taken for diagnostic local incision and biopsy of the left volar forearm. Grocott’s methenamine silver and periodic acid–Schiff staining revealed fungal organisms resembling Histoplasma and intraoperative fungal cultures grew Histoplasma capsulatum confirming the diagnosis. The patient was treated with a 6-month course of itraconazole with improvement in his condition and eventual complete resolution.

  • infectious diseases
  • dermatology
View Full Text

Statistics from


  • Patient consent for publication Obtained.

  • Contributors MSK: resident physician on case and wrote the initial manuscript. VP: consultant involved in care, edited the case and provided the images.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.