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EBUS-TBNA diagnosis of localised amyloidosis presenting as mediastinal lymphadenopathy
  1. Avnee Kumar,
  2. Barathi Sivasailam,
  3. Ellen Marciniak and
  4. Janaki Deepak
  1. Department of Medicine, University Of Maryland School Of Medicine, Baltimore, Maryland, USA
  1. Correspondence to Dr Janaki Deepak, jadeepak{at}


Amyloidosis is a unique disease of localised or systemic deposition of the abnormal extracellular fibril. Localised amyloidosis generally takes a benign course, while systemic requires treatment. Adenopathy, especially mediastinal adenopathy, is an unusual manifestation of localised amyloidosis and often requires mediastinoscopy or surgical resection for diagnosis. With the advent of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), there is potential for a less invasive diagnostic approach. We report a rare case of localised mediastinal amyloidosis diagnosed by EBUS-TBNA.

  • radiology
  • lung function

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  • Contributors AK: substantial contribution via analysis and interpretation of data, drafting and critical revision of the report; final approval of version submitted. BS: substantial contribution via interpretation of data in addition to drafting and critically revising the report; final approval of version submitted. EM and JD: substantial contribution via acquisition and analysis of data on the patient, in addition to critical revision of the report; final approval of version submitted.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.