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CASE REPORT
Influenza-induced rhabdomyolysis
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  • Published on:
    Influenza-induced rhabdomyolysis
    • Fernando Galan, Professor of Internal Meddicine University of Seville

    Influenza-induced rhabdomyolysis by Martin Brunnstrom et al 1 has called my attention because they refer to the patient's story "A man aged 29 years with a past medical history of cerebral palsy, seizures and chronic constipation".
    The authors refer to "Other causes for rhabdomyolysis were investigated and excluded" and "A muscle biopsy ruling out an underlying metabolic myopathy or polymyositis to identify a risk factor for rhabdomyolysis was not obtained."
    My comments are related to cerebral palsy and seizures.
    Can these manifestations be warning signs of an underlying metabolic or mitochondrial disease?
    Then the rhabdomyolysis could be a manifestation, for example of a mitochondrial disease exacerbated by an infection.
    Cerebral palsy (CP) is defined by its nonprogressive features. Characterization of CP is traditionally based on the predominant quality of motor impairment (spastic, dyskinetic, ataxic-hypotonic or mixed, assessed on standard neurologic examination 2
    A number of neurodegenerative, including metabolic and genetic disorders may present with similar symptoms and signs. 3
    The presence of dyskinesia or spastic quadriplegic in clinical examination, in addition to abnormal findings in neuroimaging such as syrinx malformation, cerebellar hypoplasia, white matter paucity, and abnormal signal in basal ganglia may warrant further investigation for a disorder other than CP. As inborn errors...

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    Conflict of Interest:
    None declared.