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Treatment of advanced stage methotrexate-associated lymphoproliferative disorders (MTX-LPDs) with methotrexate discontinuation
  1. Yael Ross1 and
  2. Mohammad Kamran2
  1. 1 GME Internal Medicine, WellStar Kennestone Hospital, Marietta, Georgia, USA
  2. 2 GME Internal Medicine, WellStar Kennestone Regional Medical Center, Marietta, Georgia, USA
  1. Correspondence to Dr Yael Ross, yross86{at}


We present two cases of patient’s with long-standing autoimmune diseases being treated with immunosuppressants that developed aggressive lymphoproliferative disorders. Immunosuppressants have a well-known association with disorders. Sustained regression of these lymphoproliferative disorders occurred with simple discontinuation of these immunosuppressive agents.

  • rheumatology
  • rheumatoid arthritis
  • musculoskeletal syndromes
  • therapeutic indications
  • malignant disease and immunosuppression

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  • Patient consent for publication Obtained.

  • Contributors MK discovered these cases in his patients and brought these cases to my attention and discussed writing them up. He also was instrumental in helping me obtain patient files and consents. He also reviewed the article prior to submission to ensure everything necessary was included. Without him this article would not be possible. YR wrote the article after these cases were brought to her attention by MK. She reviewed all relevant patient data and images and included them in her write up of these cases.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.