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Multifocal granular cell tumour of the biliary tree
  1. Felip Vilardell1,
  2. Marina Pardina2,
  3. Jorge Juan Olsina3 and
  4. Xavier Matias-Guiu4
  1. 1 Department of Surgical Pathology, Hospital Universitari Arnau de Vilanova and Institut de Recerca Biomèdica de Lleida, Lleida, Spain
  2. 2 Department of Radiology, Hospital Universitari Arnau de Vilanova, Lleida, Spain
  3. 3 Department of Gastrointestinal Surgery, Hospital Universitari Arnau de Vilanova, Lleida, Spain
  4. 4 Department of Molecular Pathology, Hospital Universitari Arnau de Vilanova, Lleida, Spain
  1. Correspondence to Dr Felip Vilardell, fvilardell.lleida.ics{at}


Fewer than 90 cases of granular cell tumour (GCT) of the biliary tract have been reported, including only five cases of multiple GCTs. We present the unusual case of a 40-year-old woman with multifocal GCTs affecting the intrahepatic biliary tree, which were initially suspected to be hepatic multiple metastases from a malignancy of unknown origin. The surgical specimen consisted of a hepatic segment in which five whitish nodular lesions were observed. On microscopic examination, nodular lesions were found in the portal tracts; these were composed of large polygonal cells with abundant highly granular cytoplasm. The nuclei were small and centrally located. The tumour cells tested diffusely positive for CD68-PGM1, S100 protein and α-inhibin, so a diagnosis of multifocal GCT of the biliary tree was made. Three years later, the patient is still alive and a MRI has shown no changes.

  • pathology
  • gastrointestinal surgery
  • radiology

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  • Contributors FV: case report design, writing the paper. MP: imaging advisor, writing imaging description. JJO and XM-G: case report design, redaction advisor.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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