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Case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology
  1. Jenan Ghaith1,
  2. Ismail A Raslan1,
  3. Andrew Szilagyi2 and
  4. Mona Alameldin3
  1. 1 Internal Medicine Residency Program, University of McGill, Montreal, Quebec, Canada
  2. 2 Medicine Division of Gastroenterology, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
  3. 3 Department of Pathology, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
  1. Correspondence to Dr Jenan Ghaith, jenanghaith{at}


Olmesartan-associated enteropathy (OAE) is increasingly being recognised as a major differential diagnosis in patients with villous atrophy and negative coeliac disease (CD) serology. OAE and positive coeliac markers have rarely been reported. We report a case of diarrhoea and small bowel villous blunting associated with a transient elevation of antitissue transglutaminase antibody (ATTG). On discontinuation of olmesartan, symptoms improved, repeat biopsies were normal and levels of ATTG also returned normal. We discuss a possible explanation for the transient elevation in ATTG and the significance of considering OAE/CD overlap.

  • drug interactions
  • gastrointestinal system
  • drugs: gastrointestinal system
  • coeliac disease
  • malabsorption

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  • Contributors Conception and design of study: JG, AS, IR. Acquisition of data: JG, AS. Analysis and interpretation of data: JG, AS, IR, MA. Drafting the manuscript: JG, AS, IR. Revising the manuscript critically for important intellectual content: JG, AS, IR, MA. Explaining and obtaining the consent from the patient: AS.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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