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Successful outcome after spontaneous first trimester intra-amniotic haematoma and early preterm premature rupture of membranes
  1. Spyros Bakalis1 and
  2. Anna L David2,3
  1. 1 Department of Obstetrics, Maternal and Fetal Medicine, Guy’s and Saint Thomas’ NHS Foundation Trust, London, UK
  2. 2 Director, EGA Institute for Women’s Health, University College London, London, UK
  3. 3 Research Department of Maternal Fetal Medicine, NIHR University College London Hospitals Biomedical Research Centre, London, UK
  1. Correspondence to Dr Spyros Bakalis, spyros{at}


A spontaneous intra-amniotic haematoma is a rare cause of preterm premature rupture of the membranes (PPROM) but can have significant fetal and maternal consequences. It has previously been reported to occur in the second and third trimesters but not in an earlier gestation. We present a case that presented acutely in the first trimester of pregnancy, which leads to early PPROM at 15 weeks and spontaneous preterm delivery at 28 weeks of gestation. There were no maternal complications during the pregnancy.

  • obstetrics and gynaecology
  • pregnancy

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  • Contributors Both authors managed the patient’s pregnancy from first visit until delivery. ALD: searched the literature; approved the final draft. SB: wrote the article; accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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