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Potassium chloride mixture may maintain hypokalaemia and hypertension
  1. Mette Johannsen Mandoe1,
  2. Rikke Borg2,3 and
  3. Ditte Hansen1,3
  1. 1 Department of Nephrology, Herlev Hospital, Herlev, Denmark
  2. 2 Department of Medicine, Zealand University Hospital, Roskilde, Denmark
  3. 3 Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
  1. Correspondence to Dr Rikke Borg, rbor{at}


Hypokalaemia can be treated with potassium chloride mixture. Some mixtures contain liquorice extract (glycyrrhizin) as a supplement to improve taste. Glycyrrhizin can cause pseudohyperaldosteronism and thereby result in hypertension and hypokalaemia. We here present a case where treatment with potassium chloride mixture causes hypertension and hypokalaemia in a 50-year-old woman. After unravelling differential diagnosis, the potassium chloride mixture was stopped. After the discontinuation, the patient’s blood pressure was well managed and the potassium levels normalised.

  • fluid electrolyte and acid-base disturbances
  • hypertension
  • cardiovascular system
  • contraindications and precautions
  • endocrine system
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  • Patient consent for publication Obtained.

  • Contributors MJM, RB and DH were all involved in analysing the case, interpretation of outcome, drafting the article and in revision of drafts. DH was also involved in direct patient care. All authors have seen and approved final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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