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Möbius syndrome associated with obesity and precocious puberty
  1. Samantha Roshani De Silva1,
  2. Sally L Painter1 and
  3. Darius Hildebrand1,2
  1. 1 Oxford Eye Hospital, John Radcliffe Hospital, Oxford, Oxfordshire, UK
  2. 2 Eye Unit, Royal Berkshire NHS, Reading, UK
  1. Correspondence to Mr Darius Hildebrand, dariushildebrand{at}


Möbius syndrome is a neurological disorder involving underdevelopment of the sixth and seventh cranial nerves. Multiple associations have been described including dysfunction of other cranial nerves, limb abnormalities and hypogonadotrophic hypogonadism causing delayed puberty. We present the second reported case of Möbius syndrome associated with obesity and with precocious puberty. These features may be secondary to dysregulation of the hypothalamic–pituitary axis. We highlight the need to consider extraocular symptoms in these patients and for close liaison with physicians in their management.

  • ophthalmology
  • cranial nerves

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  • Contributors SRDS and SLP collected data. SRDS drafted the manuscript, SLP and GDH edited and approved the final submission. GDH was the consultant responsible for patient care.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.