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Unusual association of diseases/symptoms
CASE REPORT
Agenesis of the corpus callosum with interhemispheric cyst: clinical implications and outcome
  1. Krishna Gopagondanahalli Revanna1,
  2. Victor Samuel Rajadurai1,2,3,4 and
  3. Suresh Chandran1,2,3,4
  1. 1 Neonatology, KK Women’s and Children’s Hospital, Singapore
  2. 2 Duke NUS Medical School, Singapore
  3. 3 NUS Yong Loo Lin School of Medicine, Singapore
  4. 4 Lee Kong Chian School of Medicine, Singapore
  1. Correspondence to Professor Suresh Chandran, schandran1312{at}yahoo.co.uk

Abstract

We describe two cases of agenesis of the corpus callosum (ACC) with interhemispheric cyst (IHC). Case 1: a male infant was born at 36 weeks gestation with a history of second trimester fetal ultrasound (US) scan and MRI showing ACC with IHC. His head circumference at birth and 5 months was at 90th centile. He developed infantile spasm and electroencephalogram showed hypsarrhythmia at 5 months of age. Seizures were controlled. He is under evaluation for surgical treatment. Case 2: ACC with a midline cyst was reported in the midtrimester US scan of a male infant. Subsequent fetal scans showed increasing size of the cyst. At birth, he had macrocephaly with a head circumference above 97th centile. MRI of the brain confirmed ACC with IHC. The parents refused a cystoperitoneal shunt offered. The child displayed gross neurodevelopmental delay with progressive hydrocephalus on follow-up and succumbed to aspiration pneumonia at 22 months of age.

  • neuroimaging
  • hydrocephalus
  • epilepsy and seizures

https://doi.org/10.1136/bcr-2018-227366

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    Footnotes

    • Contributors KGR: manuscript preparation and literature review. SC and VSR: manuscript preparation, literature review and finalisation of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Parental/guardian consent obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.