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Rare presentation of cutaneous cryptococcosis in advanced HIV
  1. Venkateshwaran Sivaraj1,
  2. Ranjababu Kulasegaram1,
  3. William Rickaby1 and
  4. Ellen Dwyer2
  1. 1 Guy’s and St Thomas' NHS Foundation Trust, London, UK
  2. 2 Berkshire Healthcare NHS Foundation Trust, Bracknell, UK
  1. Correspondence to Dr Venkateshwaran Sivaraj, drsvenkateshwaran{at}


Cryptococcus neoformans is an encapsulated yeast which causes opportunistic infection in the context of immunosuppression, including advanced HIV infection. Cryptococcal infection is systemic and can result in a fatal meningoencephalitis. Cutaneous lesions occur in 15% of those with systemic cryptococcosis and may be the first indicator of infection. Identification of these lesions may therefore expedite diagnosis and access to treatment. Cutaneous lesions typically present as papulonodular molluscum-like lesions; however, may vary significantly in appearance. We describe a rare case of extraneuronal cryptococcal infection manifesting as large subcutaneous tumours in a patient with advanced HIV-related immune deficiency.

  • HIV / AIDS
  • dermatology

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  • Contributors VS: Main author of this case report involved in diagnosis and management of this case as the ward registrar. Authored major part of this article both clinical and referencing. RK: Consultant in charge for clinical decision and management of this case. Final reviewer of this case report for accuracy and relevancy. WR: Contributor to histopathology diagnosis of this case and also provider of pictures of histopthalogy specimen for this case report. ED: Consultant in charge for management of this case while in the ward. Also authored clinical part of this case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.