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CASE REPORT
Neuroleptic malignant-like syndrome causing thrombocytopaenia: a rare association
  1. Harsh Sahu,
  2. Mouna Bidarguppe Manjunath,
  3. Animesh Ray and
  4. Naval Kishore Vikram
  1. Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India
  1. Correspondence to Dr Animesh Ray, doctoranimeshray{at}gmail.com

Abstract

Neuroleptic malignant-like syndrome is a rare but potentially fatal complication of sudden withdrawal of dopaminergic drugs. Clinical features are similar to that of neuroleptic malignant syndrome (NMS) like hyperthermia, autonomic dysfunction, altered sensorium, muscle rigidity; but instead of history of neuroleptic use, there is history of withdrawal of dopaminergic drugs. Laboratory examination generally show elevated creatine phosphokinase levels and may show elevated total leucocyte count. Thrombocytopaenia has been very rarely reported with NMS but it has not been reported with NM-like syndrome. Here, we discuss a case of Parkinson’s disease which presented with typical clinical features and risk factors of NM-like syndrome associated with thrombocytopaenia and type 1 respiratory failure. He was treated with bromocriptine and supportive care. Thrombocytopaenia and respiratory failure resolved with above treatment. The patient improved clinically and was successfully discharged on day 12 of admission.

  • Parkinson’s disease
  • neurology (drugs and medicines)
  • medical management
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Footnotes

  • Contributors HS contributed in treating the patient, planning and reporting the manuscript. He gave final approval and is accountable for case report. MBM contributed in treating the patient,acquisition of data and drafting the manuscipt. She gave final approval and is accountable for case report. AR (corresponding author) contributed in treating the patient, formation of concept for the case report, analysis and interpretation of data, revising the manuscript. He gave final approval and is accountable for case report. NKV contributed in analysis and interpretation of data, revising the manuscript. He gave final approval and is accountable for case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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