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Toxic anterior segment syndrome following phakic posterior chamber IOL: a rarity
  1. Archita Singh,
  2. Noopur Gupta,
  3. Vinod Kumar and
  4. Radhika Tandon
  1. Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India
  1. Correspondence to Professor Radhika Tandon, radhika_tan{at}


Implantable collamer lenses (ICL) have gained popularity for correction of myopia where kerato-refractive procedures are not indicated as in cases of high myopic refractive errors. Toxic anterior segment syndrome (TASS) is a very uncommonly reported postoperative complication following ICL implantation. A young patient developed severe corneal oedema and anterior segment inflammation on the first day after ICL implantation. Analysing retrospectively, possible idiosyncratic response to intracameral pilocarpine was considered as a cause for TASS. Prompt and intensive therapy with oral and topical potent steroids was visually rewarding. TASS, though a sterile inflammation can have catastrophic sequelae such as corneal decompensation and secondary glaucoma. Hence, timely identification and management is important.

  • eye
  • anterior chamber

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  • Contributors RT: conceptualised and helped in collecting data, analysis, interpretation and drafting of the manuscript. AS: was involved in data collection, analysis, interpretation and drafting of the manuscript. NG, VK: were involved in data collection, interpretation and drafting of the manuscript. All the authors have critically reviewed and approved the final draft of the manuscript. All authors agree to be accountable for the article and to ensure that all questions regarding the accuracy or integrity of the article are investigated and resolved.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.