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Atypical presentation of progressive young onset dementia
  1. Bushra Elhusein,
  2. Ahmed Radwan,
  3. Abdalla Khairi and
  4. Mohamed Ahmed
  1. Mental Health Services, Department of Medical Education, Hamad Medical Corporation, Doha, Qatar
  1. Correspondence to Dr Ahmed Radwan,{at}


We present the case of a 34-year-old Jordanian woman who was referred to mainstream mental health services because of irritability, agitation, loss of appetite, withdrawal from family activities and sleeping difficulties. She was initially diagnosed with major depressive disorder but subsequently showed very poor response to antidepressant therapy. Her presentation gradually and dramatically progressed into full blown dementia within couple of years. Brain MRI showed atrophic cortical changes and subcortical white matter alterations consistent with Alzheimer’s dementia. Brain PET scan revealed reduction in cerebral glucose metabolism in temporoparietal areas bilaterally most consistent with Alzheimer’s dementia. There was a strong family history of early-onset dementia. A final diagnosis of young onset dementia was made, and unfortunately, she passed away at the age of 44 years.

  • dementia, alzheimer’s type
  • disability
  • depressive disorder

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  • Contributors BE was the principal investigator and resident assigned to interview and assess the patient. AR was responsible for home visits and met with the patient family members. AK is a consultant geriatric psychiatrist who helped us as adult psychiatry team to establish dementia diagnosis and he interviewed the patient many times. MA is a senior consultant, community mental health psychiatrist and the team leader. He is the reference for all aspects related to this patient. All the authors met regularly to discuss the patient case and to write the final case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Next of kin consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.