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  • Bilateral neovascular age-related macular degeneration: unilateral regression following endophthalmitis with persistent activity in the fellow eye

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Case Reports: Unusual association of diseases/symptoms
Bilateral neovascular age-related macular degeneration: unilateral regression following endophthalmitis with persistent activity in the fellow eye
  1. Sandhya Gaur1,
  2. Deependra Vikram Singh1,
  3. Raja Rami Reddy2 and
  4. Ajay Sharma1
  1. 1Retina Services, Eye-Q Superspecialty Eye Hospitals, Gurugram, Haryana, India
  2. 2Retina Services, Neo Retina Eye Institute, Nampalli, Hyderabad, India
  1. Correspondence to Dr Deependra Vikram Singh; deependravsingh{at}hotmail.com

Abstract

A woman in her 70s who was being followed up for neovascular age-related macular degeneration (nAMD) in both eyes for 2 years with recalcitrant choroidal neovascularisation (CNV) and had an episode of acute endophthalmitis in one eye was identified. After treatment of postinjection culture-negative right eye (RE) endophthalmitis with intravitreal vancomycin and tazobactam, the patient had complete regression of treatment-resistant CNV in RE to date with postinfection follow-up of 2 years. In contrast, the fellow eye continued showing activity in the choroidal neovascular membrane that required antivascular endothelial growth factor injections on a pro re nata basis to date. Prolonged regression of nAMD for 3 years in the affected eye and continued activity in the fellow eye support the hypothesis that inflammation accompanying endophthalmitis or the drugs used for the treatment can have a role in the regression of nAMD.

  • Retina
  • Macula

https://doi.org/10.1136/bcr-2021-244771

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    Footnotes

    • Contributors SG: conceptualisation, data curation, supervision, visualisation and writing (original draft, review and editing); DVS: conceptualisation, data curation, project administration, resources, validation, visualisation and writing (original draft, review and editing); RRR: conceptualisation, writing (original draft, review and editing); AS: conceptualisation, validation, writing (review and editing).

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.