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Case report
Paraneoplastic optic neuropathy secondary to adenocarcinoma of the lung
  1. Jin Yi Yap1,2,
  2. Wan-Hazabbah Wan HItam3,
  3. Sanihah Abdul Halim4 and
  4. Nurul Ain Masnon5
  1. 1Ophthalmology, University of Science Malaysia School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia
  2. 2Surgical Department, University of Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia
  3. 3University of Science Malaysia—Health Campus, Kubang Kerian, Malaysia
  4. 4Department of Medicine, University of Science Malaysia—Kesihatan Campus, Kubang Kerian, Kelantan, Malaysia
  5. 5Department of Ophthalmology, University of Science Malaysia—Kesihatan Campus, Kubang Kerian, Kelantan, Malaysia
  1. Correspondence to Dr Jin Yi Yap; yjy16my{at}yahoo.com

Abstract

We describe an uncommon cause of paraneoplastic optic neuropathy in adenocarcinoma of the lung. A 45-year-old healthy woman presented with seizure and encephalitis, followed by an acute visual loss in both eyes for 1 week. Her visual acuity was no perception of light in the right eye and hand movement in the left eye. There was a generalised restriction of extraocular muscle movements in both eyes. Funduscopy showed a bilateral pale optic disc. A paraneoplastic antigen autoimmune profile showed a positive anti-CV2/CRMP-5 antibody. CT of the thorax revealed the presence of right apical lung mass, confirmed to be adenocarcinoma through a biopsy. She was scheduled for lung lobectomy and chemotherapy. Unfortunately, her health deteriorated and she passed away eventually.

  • cancer intervention
  • neuro-oncology
  • neuro-ophthalmology
  • lung cancer (oncology)

https://doi.org/10.1136/bcr-2021-242082

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    Footnotes

    • Contributors JYY was one of the physicians in charge of the patient we reported; responsible for writing up the case presentation and data collection, including the consent taking and obtaining the images;and involved in the literature review of the case report as well. W-HWH was the main physician in charge of the patient; provided important intellectual content for the discussion of the write up of the case presentation; and finalised the case report before submission. SAH was the neurologist in charge of the patient; provided expert opinion to co-manage the patient; and provided important intellectual content for the discussion of the case report. NAM was the physician in charge of the patient; assisted in data collection and provided intellectual content for the discussion of the case report.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.