Clinical experiences with naltrexone in 370 detoxified addicts

NIDA Res Monogr. 1976 Sep:(9):88-92. doi: 10.1037/e497452006-017.

Abstract

Our studies have shown no evidence of toxicity and few side effects from naltrexone. It is a valuable adjunct in treating addicts who wish to be opiate free. Patients who drop out and return to treatment tend to remain longer with each successive readmission. Naltrexone has special potential for persons, such as an opiate-abusing physician for whom methadone maintenance is clearly inappropriate. A double-blind study has suggested that it may have value as a transitional treatment for detoxified methadone maintenance patients. Differences between naltrexone and cyclazocine suggest that a treatment combining these drugs should be explored.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Clinical Trials as Topic
  • Cyclazocine / therapeutic use
  • Drug Administration Schedule
  • Humans
  • Methadone / administration & dosage
  • Methadone / therapeutic use
  • Naloxone / analogs & derivatives*
  • Naltrexone / adverse effects
  • Naltrexone / therapeutic use*
  • Patient Compliance
  • Physicians
  • Placebos
  • Research Personnel
  • Substance-Related Disorders / rehabilitation*

Substances

  • Placebos
  • Naloxone
  • Naltrexone
  • Cyclazocine
  • Methadone