In the mid-1980s, the incidence of tuberculosis (TB) in the United States increased. Recently, TB became an index diagnosis for AIDS. Chest radiographs in patients with AIDS and TB may be atypical; various features are addressed in this article. Radiologists should be aware of the possibility of TB because this disease is not only communicable to health care workers and other patients but more recently has become difficult to treat because of multidrug-resistant Mycobacterium tuberculosis.