Case of keratoacanthoma centrifugum marginatum treated with acitretin

BMJ Case Rep. 2018 Nov 1:2018:bcr2018226818. doi: 10.1136/bcr-2018-226818.

Abstract

Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA), characterised by a progressively expanding tumour with a lack of spontaneous remission and significant scarring. KCM has been reported previously in less than 50 cases worldwide. We present the case of a large solitary KCM on the right shin of a 71-year-old woman. This was treated successfully with oral acitretin for 16 months with sustained remission at 24 months. Our case provides further supporting evidence for acitretin as a useful treatment for KCM to induce remission, prevent extensive surgery and minimise destructive scarring.

Keywords: dermatology; skin cancer.

Publication types

  • Case Reports

MeSH terms

  • Acitretin / administration & dosage
  • Acitretin / therapeutic use*
  • Administration, Oral
  • Aged
  • Cicatrix / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Keratoacanthoma / classification
  • Keratoacanthoma / drug therapy*
  • Keratoacanthoma / pathology
  • Keratolytic Agents / administration & dosage
  • Keratolytic Agents / therapeutic use*
  • Rare Diseases
  • Remission Induction
  • Treatment Outcome

Substances

  • Keratolytic Agents
  • Acitretin