Unusual case of iron overload with cancer-mimicking abdominal splenosis

BMJ Case Rep. 2018 May 16:2018:bcr2017223410. doi: 10.1136/bcr-2017-223410.

Abstract

A 48-year-old man, former alcohol abuser and drug addicted, was referred to our tertiary referral centre for iron disorders because of marked hyperferritinaemia. His clinical history revealed chronic hepatitis C, ß-thalassaemia trait and post-traumatic splenectomy at age of 22. MRI-estimated liver iron content was markedly elevated, while first-line genetic test for haemochromatosis was negative. Alpha-fetoprotein was increased but liver ultrasonography did not reveal focal liver lesions. Multiphasic contrast-enhanced CT confirmed this result but showed two abdominal masses (diameter of 9 cm and 7 cm, respectively) among bowel loops, strongly suspicious for cancer. However, biopsy of one of the masses led to the final diagnosis of abdominal splenosis.

Keywords: haematology (incl blood transfusion); liver disease; radiology.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Neoplasms / diagnosis
  • Diagnosis, Differential
  • Humans
  • Iron Overload / diagnosis*
  • Liver / diagnostic imaging
  • Liver / pathology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Splenectomy / adverse effects*
  • Splenosis / diagnosis*
  • Splenosis / etiology*
  • Stomach Diseases / diagnosis*