Anorectal involvement in a patient with multiple myeloma

BMJ Case Rep. 2017 Apr 18:2017:bcr2017219658. doi: 10.1136/bcr-2017-219658.

Abstract

Multiple myeloma is a neoplastic proliferation of monoclonal plasma cells. Symptomatic gastrointestinal involvement is uncommon. We report the case of a 45-year-old patient admitted with an anorectal polypoid lesion, which progressed to colonic obstruction. Investigation revealed a secondary plasmacytoma associated with multiple myeloma. We discuss the characteristics of this rare entity with poor prognosis, its clinical implications and treatment options.

Keywords: Gastrointestinal system; Haematology (incl blood transfusion); Malignant disease and immunosuppression.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / therapeutic use
  • Dexamethasone / administration & dosage
  • Dexamethasone / therapeutic use
  • Fatal Outcome
  • Humans
  • Male
  • Middle Aged
  • Multiple Myeloma / surgery*
  • Plasmacytoma / secondary*
  • Prognosis
  • Retroperitoneal Neoplasms / diagnosis*
  • Retroperitoneal Neoplasms / drug therapy
  • Retroperitoneal Neoplasms / surgery
  • Sigmoidoscopy
  • Teniposide / administration & dosage
  • Teniposide / therapeutic use

Substances

  • Dexamethasone
  • Cyclophosphamide
  • Teniposide

Supplementary concepts

  • VCD protocol