Occurrence and new mutations involved in rifampicin-resistant Propionibacterium acnes strains isolated from biofilm or device-related infections

Anaerobe. 2015 Aug:34:116-9. doi: 10.1016/j.anaerobe.2015.05.003. Epub 2015 May 18.

Abstract

We described for the first time the amino acid substitutions conferring rifampicin resistance in eight Propionibacterium acnes strains isolated from patients with biofilm or device-related infections. We identified different mutations in cluster I and one mutation, never reported, in cluster II of the rpoB gene (I480V) associated with the most frequent one in cluster I (S442L). Half of the patients previously received treatment with rifampicin.

Keywords: Biofilm; Foreign-body infection; Propionibacterium acnes; Resistance; Rifampicin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amino Acid Substitution
  • Anti-Bacterial Agents / pharmacology
  • Biofilms*
  • Catheter-Related Infections / microbiology*
  • DNA-Directed RNA Polymerases / genetics*
  • Drug Resistance, Bacterial*
  • Female
  • Gram-Positive Bacterial Infections / microbiology
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Mutation, Missense*
  • Propionibacterium acnes / drug effects*
  • Propionibacterium acnes / isolation & purification
  • Rifampin / pharmacology*
  • Sequence Analysis, DNA

Substances

  • Anti-Bacterial Agents
  • DNA-Directed RNA Polymerases
  • RNA polymerase beta subunit
  • Rifampin

Associated data

  • GENBANK/KC433659
  • GENBANK/KC433660
  • GENBANK/KC433661
  • GENBANK/KC433662
  • GENBANK/KC433663
  • GENBANK/KC433664
  • GENBANK/KJ000556
  • GENBANK/KJ486153