A case of nearly mistaken AB para-Bombay blood group donor transplanted to a group 'O' recipient

BMJ Case Rep. 2014 Oct 31:2014:bcr2014206374. doi: 10.1136/bcr-2014-206374.

Abstract

Unintentional ABO mismatch kidney transplantation can cause detrimental hyperacute rejection. We report the first successful ABO incompatible kidney transplantation from an AB para-Bombay donor to O recipient. At the initial evaluation, the donor's ABO type was discordance on the cell typing and serum typing, which typed to be 'O' as cell typing and 'AB' as serum typing. At the second investigation, it was confirmed that the donor had a unique, rare but not uncommon blood type AB para-Bombay which was incompatible with the recipient's blood group. The kidney transplantation was successfully performed by an ABO incompatible preconditioning, double filtration plasmapheresis (DFPP) and rituximab. The serum creatinine at 12 months post-transplantation was 1.3 mg/dL. The pathology of the kidney biopsy showed no signs of rejection.

Publication types

  • Case Reports

MeSH terms

  • ABO Blood-Group System
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Blood Group Antigens*
  • Blood Group Incompatibility / therapy*
  • Female
  • Graft Rejection / prevention & control*
  • Humans
  • Kidney Transplantation*
  • Middle Aged
  • Plasmapheresis / methods
  • Rituximab
  • Tissue Donors
  • Transplantation Conditioning / methods*

Substances

  • ABO Blood-Group System
  • Antibodies, Monoclonal, Murine-Derived
  • Blood Group Antigens
  • Rituximab