Severe CMV complication following maintenance therapy with rituximab

BMJ Case Rep. 2013 Jan 9:2013:bcr2012006672. doi: 10.1136/bcr-2012-006672.

Abstract

Cytomegalovirus (CMV) encephalitis is a rare infection that immunodeficient patients, mainly where HIV-positive, may suffer from. Several cases were described when complications with the treatment with monoclonal antibodies, like rituximab, for malignant lymphomas. We will describe here the case of a patient, who has developed CMV gastritis, then CMV encephalitis after the treatment of a CLL with a chemotherapy and maintenance therapy with rituximab.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal, Murine-Derived / adverse effects*
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Antibodies, Viral / analysis*
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use
  • Cytomegalovirus / immunology*
  • Cytomegalovirus Infections / diagnosis
  • Cytomegalovirus Infections / etiology*
  • Follow-Up Studies
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
  • Male
  • Rituximab
  • Severity of Illness Index

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • Antibodies, Viral
  • Antineoplastic Agents
  • Rituximab