Rosuvastatin-induced pemphigoid

BMJ Case Rep. 2012 May 8:2012:bcr1120115180. doi: 10.1136/bcr.11.2011.5180.

Abstract

Statins are widely prescribed medications and very well tolerated. Rosuvastatin is another member of this drug used to treat dyslipidaemia. It is a competitive inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase. Immunobullous disease is usually idiopathic but can be drug-induced. Both idiopathic and iatrogenic forms share common clinical and immunohistological features. The authors report a case of pemphigoid induced by rosuvastatin, a commonly prescribed medication. To our knowledge, there is limited report on rosuvastatin associated with pemphigoid in the literature.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Dyslipidemias / drug therapy*
  • Female
  • Fluorescent Antibody Technique
  • Fluorobenzenes / adverse effects*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Middle Aged
  • Pemphigoid, Bullous / chemically induced*
  • Pyrimidines / adverse effects*
  • Rosuvastatin Calcium
  • Sulfonamides / adverse effects*

Substances

  • Fluorobenzenes
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrimidines
  • Sulfonamides
  • Rosuvastatin Calcium