A case of bullous disease limited to the skin illustrates the spectrum of neoplasia-induced autoimmunity

Dermatol Online J. 2009 Jul 15;15(7):5.

Abstract

Although the initial report of paraneoplastic pemphigus described individuals with mucocutaneous blistering disease, subsequent reports identified patients with lichen planus or graft versus host disease-like changes. We describe a patient with fatal autoimmune blistering disease with absence of mucous membrane lesions. The pattern of complement indirect immunofluoresence helped identify the prognosis prospectively. This case illustrates yet another presentation of the neoplasia-induced autoimmunity.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Antibodies, Antinuclear / immunology
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / etiology*
  • Autoimmune Diseases / pathology
  • Complement Fixation Tests
  • Cyclophosphamide / administration & dosage
  • Diagnosis, Differential
  • Fatal Outcome
  • Female
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • Lymphoma, Non-Hodgkin / complications*
  • Lymphoma, Non-Hodgkin / drug therapy
  • Lymphoma, Non-Hodgkin / immunology
  • Paraneoplastic Syndromes / diagnosis
  • Paraneoplastic Syndromes / etiology*
  • Paraneoplastic Syndromes / immunology
  • Paraneoplastic Syndromes / pathology
  • Pemphigus / diagnosis
  • Prednisone / administration & dosage
  • Rituximab
  • Sepsis / complications
  • Skin Diseases, Vesiculobullous / diagnosis
  • Skin Diseases, Vesiculobullous / etiology*
  • Skin Diseases, Vesiculobullous / immunology
  • Skin Diseases, Vesiculobullous / pathology
  • Vincristine / administration & dosage

Substances

  • Antibodies, Antinuclear
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Rituximab
  • Vincristine
  • Cyclophosphamide
  • Prednisone