Abstract
Background:
Infectious complications of intravesical bacillus Calmette-Guérin (BCG) therapy are rare, but these have included a handful of cases of mycotic aneurysm.
Methods and results:
We present the case of a patient with a ruptured abdominal aortic aneurysm and a femoral artery aneurysm who had previously received intravesical BCG therapy for bladder carcinoma. Histopathologic examination of resected tissue revealed numerous acid-fast bacilli, and subsequent mycobacterial culture of blood and resected tissue revealed BCG strain Mycobacterium bovis.
Conclusions:
Clinicians should be aware of the possible extravesical complications, albeit rare, of BCG therapy. Therapy should consist of combined medical and surgical management.
MeSH terms
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Administration, Intravesical
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Aged
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Aneurysm, Infected / microbiology*
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Aneurysm, Infected / pathology
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Aneurysm, Infected / surgery
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Antitubercular Agents / therapeutic use
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Aortic Aneurysm, Abdominal / microbiology*
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Aortic Aneurysm, Abdominal / pathology
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Aortic Aneurysm, Abdominal / surgery
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Aortic Rupture / microbiology
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Aortic Rupture / pathology
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Aortic Rupture / surgery
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BCG Vaccine / adverse effects*
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Femoral Artery / microbiology
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Femoral Artery / pathology
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Humans
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Male
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Mycobacterium bovis / isolation & purification*
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Mycobacterium bovis / physiology
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Treatment Outcome
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Tuberculosis, Cardiovascular / drug therapy
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Tuberculosis, Cardiovascular / microbiology*
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Tuberculosis, Cardiovascular / pathology
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Urinary Bladder Neoplasms / therapy*
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Vaccines, Attenuated / adverse effects
Substances
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Antitubercular Agents
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BCG Vaccine
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Vaccines, Attenuated